Nickel‐Catalyzed Dimerization and Alkylarylation of 1,3‐Dienes with Alkyl Fluorides and Aryl Grignard Reagents |
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Authors: | Dr. Takanori Iwasaki Xin Min Asuka Fukuoka Prof. Dr. Hitoshi Kuniyasu Prof. Dr. Nobuaki Kambe |
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Affiliation: | Department of Applied Chemistry, Graduate School of Engineering, Osaka University, Osaka, Japan |
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Abstract: | In the presence of a nickel catalyst, 1,3‐butadiene undergoes selective dimerization and alkylarylation with alkyl fluorides and aryl Grignard reagents to give 1,6‐octadienes with alkyl and aryl groups at the 3‐ and 8‐positions, respectively, by the consecutive formation of three carbon–carbon bonds. The formation of an anionic nickel complex plays an important role in forming C?C bonds with alkyl fluorides. |
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Keywords: | alkylation dimerization multicomponent reactions nickel regioselectivity |
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