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Direct Asymmetric Reductive Amination for the Synthesis of Chiral β‐Arylamines |
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| Authors: | Haizhou Huang Xiaoyan Liu Prof. Dr. Le Zhou Prof. Dr. Mingxin Chang Prof. Dr. Xumu Zhang |
| Affiliation: | 1. Department of Chemistry and Chemical Engineering, Northwest A&F University, Shaanxi, PR China;2. Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, NJ, USA |
| Abstract: | The highly efficient and direct asymmetric reductive amination of arylacetones catalyzed by an iridium complex for the preparation of enantiomerically pure β‐arylamines is described. The monodentate phosphoramidite ligand exhibits superb reactivity (TONs of up to 20 000) and enantioselectivity (up to 99 % ee). Additives played important roles in this reductive coupling reaction. |
| Keywords: | asymmetric catalysis enantioselectivity iridium ligand design reductions |