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Rhodium‐Catalyzed Intramolecular C−H Silylation by Silacyclobutanes |
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| Authors: | Dr. Qing‐Wei Zhang Kun An Li‐Chuan Liu Shuangxi Guo Chenran Jiang Dr. Huifang Guo Prof. Dr. Wei He |
| Affiliation: | 1. School of Pharmaceutical Sciences, Tsinghua University, Beijing, China;2. http://www.med.tsinghua.edu.cn/index.php/en/research/faculty/item/he‐wei |
| Abstract: | Silacyclobutane was discovered to be an efficient C?H bond silylation reagent. Under the catalysis of RhI/TMS‐segphos, silacyclobutane undergoes sequential C?Si/C?H bond activations, affording a series of π‐conjugated siloles in high yields and regioselectivities. The catalytic cycle was proposed to involve a rarely documented endocyclic β‐hydride elimination of five‐membered metallacycles, which after reductive elimination gave rise to a Si?RhI species that is capable of C?H activation. |
| Keywords: | C− H activation metallocycle silole silylation β -hydrogen elimination |