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Covalent Self‐Assembly and One‐Step Photocrosslinking of Tyrosine‐Rich Oligopeptides to Form Diverse Nanostructures |
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| Authors: | Dr Kyoung‐Ik Min Dr Gyeongwon Yun Dr Yoonjung Jang Kyung‐Rok Kim Dr Young Ho Ko Dr Hyung‐Seok Jang Prof?Dr Yoon‐Sik Lee Prof?Dr Kimoon Kim Prof?Dr Dong‐Pyo Kim |
| Institution: | 1. National Centre of Applied Microfluidic Chemistry, Department of Chemical Engineering, POSTECH (Pohang University of Science and Technology), Pohang, Republic of Korea;2. Center for Self-Assembly and Complexity (CSC), Institute for Basic Science (IBS), Pohang, Republic of Korea;3. Department of Chemistry, POSTECH (Pohang University of Science and Technology), Pohang, Republic of Korea;4. School of Chemical and Biological Engineering, Seoul National University, Seoul, Republic of Korea |
| Abstract: | We present covalently self‐assembled peptide hollow nanocapsule and peptide lamella. These biomimetic dityrosine peptide nanostructures are synthesized by one‐step photopolymerization of a tyrosine‐rich short peptide without the aid of a template. This simple approach offers direct synthesis of fluorescent peptide nanocages and free‐standing thin films. The simple crosslinked peptide lamella films provide robust mechanical properties with an elastic modulus of approximately 30 GPa and a hardness of 740 MPa. These nanostructures also allow for the design of peptidosomes. The approach taken here represents a rare example of covalent self‐assembly of short peptides into nano‐objects, which may be useful as microcompartments and separation membranes. |
| Keywords: | covalent self-assembly films nanocapsules peptides tyrosine– tyrosine crosslinking |