Synthesis of 2‐Indolyltetrahydroquinolines by Zinc(II)‐Catalyzed Intramolecular Hydroarylation‐Redox Cross‐Dehydrogenative Coupling of N‐Propargylanilines with Indoles |
| |
| Authors: | Dr Guangzhe Li Prof?Dr Hiroyuki Nakamura |
| |
| Institution: | Chemical Resources Laboratory, Tokyo Institute of Technology, Yokohama, Kanagawa, Japan |
| |
| Abstract: | An intramolecular hydroarylation‐redox cross‐dehydrogenative coupling (CDC) of propargylic anilines with indoles proceeded in the presence of zinc(II) catalysts to give 2‐indolyltetrahydroquinolines in good to high yields. Three C?H bonds (two sp2 and one sp3) are activated in one shot and these hydrogen atoms are trapped by a propargylic triple bond in the molecule. |
| |
| Keywords: | C− H activation cross-dehydrogenative coupling intramolecular hydroarylation tetrahydroquinoline zinc catalysts |
|
