Nickel‐Catalyzed Decarboxylative Difluoroalkylation of α,β‐Unsaturated Carboxylic Acids |
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| Authors: | Gang Li Tao Wang Fan Fei Dr Yi‐Ming Su Dr Yan Li Dr Quan Lan Prof?Dr Xi‐Sheng Wang |
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| Institution: | 1. Department of Chemistry, University of Science and Technology of China, Hefei, China;2. Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional Molecules, Chinese Academy of Sciences, Shanghai Institute of Organic Chemistry, Shanghai, China |
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| Abstract: | The first example of nickel‐catalyzed decarboxylative fluoroalkylation of α,β‐unsaturated carboxylic acids has been developed with commonly available fluoroalkyl halides. This novel transformation has demonstrated broad substrate scope, excellent functional‐group tolerance, mild reaction conditions, and excellent stereoselectivity. Mechanistic investigations indicate that a fluoroalkyl radical is involved in the catalytic cycle. |
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| Keywords: | fluoroalkylation nickel olefins radicals synthetic methods |
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