| 1R,3S-1,2,2-三甲基-1,3-环戊二胺为配体的铂髤配合物的合成、表征和抗肿瘤活性 |
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| 引用本文： | 王联红,刘芸,袁阜平,尤启冬,苟少华. 1R,3S-1,2,2-三甲基-1,3-环戊二胺为配体的铂髤配合物的合成、表征和抗肿瘤活性[J]. 无机化学学报, 2004, 0(7) |
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| 作者姓名： | 王联红 刘芸 袁阜平 尤启冬 苟少华 |
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| 作者单位： | 中国药科大学药学院，南京大学配位化学国家重点实验室，南京大学配位化学国家重点实验室，中国药科大学药学院，南京大学配位化学国家重点实验室 南京210009，南京大学配位化学国家重点实验室，南京210093，南京210093，南京210093，南京210009，南京210093 |
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| 基金项目： | 国家自然科学基金重大项目(No.20391001)资助。 |
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| 摘 要： | 本文合成了9种含有由天然D( )鄄樟脑衍生的1R,3S鄄1,2,2鄄三甲基鄄1,3鄄环戊二胺(A)为配体的铂髤配合物[Pt髤AX]{其中,X=(CH2)3C(COO-)2(1,1鄄环丁烷二羧酸根),2CH3OCH2COO-,2CH3CH2OCH2COO-,2CH3(CH2)3OCH2COO-,[OCH(CH3)COO]2-(乳酸根),(OCH2COO)2-(乙醇酸根),2CH3OCH2CH2OCH2COO-,2CH3CH2OCH2CH2OCH2COO-和2CH3(CH2)3OCH2CH2OCH2COO-}。通过元素分析、热重分析、红外光谱、1H核磁共振谱和电喷雾质谱等对配合物进行了表征。体外生物活性测试表明,部分配合物对A549人肺癌细胞和HCT鄄116人结肠癌细胞具有较强的抗肿瘤活性。
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| 关 键 词： | 1R 3S-1 2 2-三甲基-1 3-环戊二胺 铂(Ⅱ)髤配合物 抗肿瘤活性 经典构效关系 手性配体 |
Synthesis, Characterization and Antitumor Activities of a Series of Platinum(II) Complexes with 1R,3S-1,2,2-Trimethylcyclopentanediamine |
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| WANG Lian-Hong, LIU Yun YUAN Fu-Ping YOU Qi-Dong, GOU Shao-Hua. Synthesis, Characterization and Antitumor Activities of a Series of Platinum(II) Complexes with 1R,3S-1,2,2-Trimethylcyclopentanediamine[J]. Chinese Journal of Inorganic Chemistry, 2004, 0(7) |
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| Authors: | WANG Lian-Hong LIU Yun YUAN Fu-Ping YOU Qi-Dong GOU Shao-Hua |
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| Affiliation: | WANG Lian-Hong1,2 LIU Yun2 YUAN Fu-Ping2 YOU Qi-Dong*,1 GOU Shao-Hua*,2 |
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| Abstract: | Nine novel chiral platinum(II) complexes {A=1R,3S-1,2,2-trimethylcyclopentanediamine derived from natural camphor, X =(CH2)3C(COO-)2 (1,1-cyclobutanedicarboxylato), 2CH3OCH2COO-, 2CH3CH2OCH2COO-, 2CH3(CH2)3OCH2COO-, [OCH(CH3)COO]2- (lactato), (OCH2COO)2- (glycolato), 2CH3OCH2CH2OCH2COO-, 2CH3CH2OCH2CH2OCH2COO- and 2CH3(CH2)3OCH2CH2OCH2COO-} have been prepared and characterized by elemental analysis, TG thermal analysis, IR, 1H NMR and ESI-MS spectra. The cytotoxic activities of these complexes in vitro toward A549 human lung carcinoma cells and HCT-116 human colon cancer cells have been studied. Some complexes show remarkable cytotoxicity against the above-mentioned cell lines. |
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| Keywords: | R 3S-1 2 2-trimethylcyclopentanediamine platinum (II) complexes antitumor activity classical structure-activity relationships chiral ligand |
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