Electrostatic control of aromatic stacking interactions |
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| Authors: | Cockroft Scott L Hunter Christopher A Lawson Kevin R Perkins Julie Urch Christopher J |
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| Affiliation: | Centre for Chemical Biology, Department of Chemistry, Krebs Institute for Biomolecular Science, University of Sheffield, Sheffield S3 7HF, U.K. |
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| Abstract: | A supramolecular approach has been used to investigate the free energies of intermolecular aromatic stacking interactions. Chemical double mutant cycles have been used to measure the effect of a range of substituents on face-to-face stacking interactions with phenyl and pentafluorophenyl rings. Electrostatic effects dominate the trends in interaction energy. |
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