Thermal stability evaluation of doping compounds before GC-MS analysis by DSC |
| |
Authors: | Y Hadef " target="_blank">J Kaloustian " target="_blank">A Nicolay " target="_blank">H Portugal |
| |
Institution: | (1) Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, 650093 Kunming, Yunnan, China; |
| |
Abstract: | The Medical Commission of the International Olympic Committee forbids the use of anabolic androgenic steroids, β-agonists,
stimulant and narcotic compounds to improve athletic performance. In this work, we evaluated the thermal stability of 17 compounds
by the use of the DSC for their potential GC-MS analysis either under free form or under TMS derivative form. In DSC, esterified
and unesterified anabolic steroids were characterized by a true melting peak, followed by a large exothermic peak at about
251–316°C due to oxidative degradation. They could be analysed by GC-MS mainly under TMS derivatives. Hydroxylated and unhydroxylated
stimulant compounds (xanthines) seemed to be more stable at high temperature. As unhydroxylated xanthines were not silylated
with BSTFA - TMCS, their GC analysis would be done under their free forms. TMS derivatisation of albuterol hemisulfate and
codeine phosphate is preferable. In our conditions, to analyse by GC-MS all 17 doping compounds in the same GC-MS run, the
optimal silylation temperature and best column initial temperature were determined at both 60°C. |
| |
Keywords: | doping compounds DSC GC-MS thermal stability TMS derivatives |
本文献已被 SpringerLink 等数据库收录! |
|