Present status of hemoperfusion/hemodialysis in Italy |
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Authors: | V Bonomini S Stefoni G Feliciangeli L Colì M P Scolari R Prandini C U Casciani M Taccone Gallucci A Albertazzi V Mioli F Mastrangelo |
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Institution: | (1) Institute of Nephrology and Dialysis, St. Orsola University Hospital, University of Bologna, Bologna, Italy;(2) Institute of Surgical Pathology, University of Rome, Italy;(3) Department of Nephrology and Dialysis, University of Chieti, Italy;(4) Department of Nephrology and Dialysis, University of Ancona, Italy;(5) Department of Nephrology and Dialysis, Lecce, Italy |
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Abstract: | The use of charcoal hemoperfusion in the treatment of chronic renal failure has been proposed and applied by several authors.
The availability of coating membranes of increased biocompatibility currently allows a safer and wider use of this purifying
technique. It has been recently demonstrated that long-term treatment with combined hemodialysis/hemoperfusion yields an improvement
of certain dialysis-resistant uremic signs in patients on regular dialysis treatment, while in selected patients it affords
a marked reduction (up to one-third) in the overall time of treatment per week. The tolerance of long-term treatment is good.
In line with these findings, a multicenter study has been carried out in Italy with two main aims: (1) to see whether long-term
treatment with charcoal hemoperfusion is really safe and substantially free from side effects; (2) to verify in a larger and
more varied population of patients whether such long-term treatment actually improves certain uremic signs persisting despite
adequate dialysis treatment. A third phase of the multicentric study (reducing the weekly time of treatment) is currently
being worked on. Five nephrology and dialysis departments took part in the study: in Bologna, Rome, Chieti, Ancona, and Lecce. |
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Keywords: | Hemoperfusion charcoal in hemodialysis hemodialysis artificial organs uremia and hemodialysis |
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