|
|||||
|
|
Enantioselective S?H Insertion Reactions of α-Carbonyl Sulfoxonium Ylides |
|
| Authors: | Dr Patrícia B Momo M?Sc Alexandria N Leveille M?Sc Elliot H E Farrar Dr Matthew N Grayson Prof?Dr Anita E Mattson Prof?Dr Antonio C B Burtoloso |
| Institution: | 1. Institute of Chemistry of São Carlos, University of São Paulo, CEP 13560-970, São Carlos, SP Brazil;2. Department Chemistry and Biochemistry, Worcester Polytechnic Institute, 100 Institute Road, Worcester, MA, 01609 USA;3. Department of Chemistry, University of Bath, Claverton Down, Bath, BA2 7AY UK |
| Abstract: | The first example of enantioselective S?H insertion reactions of sulfoxonium ylides is reported. Under the influence of thiourea catalysis, excellent levels of enantiocontrol (up to 95 % ee) and yields (up to 97 %) are achieved for 31 examples in S?H insertion reactions of aryl thiols and α-carbonyl sulfoxonium ylides. |
| Keywords: | aryl thiol enantioselectivity organocatalysis S?H insertion sulfoxonium ylide |