Elucidating Noncovalent Reaction Mechanisms: G-Quartet as an Intermediate in G-Quadruplex Assembly |
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Authors: | Dr. Miguel Martín-Arroyo Dr. Anselmo del Prado Dr. Raquel Chamorro Dr. Nerea Bilbao Prof. David González-Rodríguez |
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Affiliation: | Nanostructured Molecular Systems and Materials (MSMn) Group, Departamento de Química Orgánica, Facultad de Ciencias, Universidad Autónoma de Madrid, 28049 Madrid, Spain |
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Abstract: | In analogy to covalent reactions, the understanding of noncovalent association pathways is fundamental to influence and control any supramolecular process. Following an approach that is reminiscent of covalent methodologies, we study here, for the first time, the mechanism of G-quadruplex formation in organic solvents. Our results support a reaction pathway in which the cation shifts the equilibrium towards a G-quartet transient intermediate, which then acts as a template in the formation of the G-quadruplex product. |
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Keywords: | G-quadruplex G-quartets guanine self-assembly noncovalent synthesis supramolecular chemistry |
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