Asymmetric Wacker-Type Oxyallenylation and Azaallenylation of Cyclic Alkenes |
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| Authors: | Shenghan Teng Dr. Zhiwei Jiao Prof. Dr. Yonggui Robin Chi Prof. Dr. Jianrong Steve Zhou |
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| Affiliation: | 1. Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore, 637371 Singapore;2. State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, 2199 Lishui Road, Room F-312, Nanshan District, Shenzhen, 518055 China |
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| Abstract: | Palladium-catalyzed three-component carboetherification of cyclic alkenes proceeded to give trans adducts exclusively with excellent enantioselectivity through a Wacker-type pathway. The reaction is also applicable to other oxygen nucleophiles, such as water, phenols, and carboxylic acids, as well as some electron-poor aryl amines. |
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| Keywords: | Allene Asymmetrische Katalyse Carboveretherung Palladiumkatalyse Wacker-Reaktion |
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