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Site-Selective Late-Stage Aromatic [18F]Fluorination via Aryl Sulfonium Salts |
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| Authors: | Dr Peng Xu Dr Da Zhao Dr Florian Berger Aboubakr Hamad Dr Jens Rickmeier Roland Petzold Mykhailo Kondratiuk Kostiantyn Bohdan Prof Dr Tobias Ritter |
| Institution: | 1. Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, Germany
These authors contributed equally to this work.;2. Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, Germany |
| Abstract: | Site-selective functionalization of C−H bonds in small complex molecules is a long-standing challenge in organic chemistry. Herein, we report a broadly applicable and site-selective aromatic C−H dibenzothiophenylation reaction. The conceptual advantage of this transformation is further demonstrated through the two-step C−H 18F]fluorination of a series of marketed small-molecule drugs. |
| Keywords: | 18F-Markierung C-H-Funktionalisierung Fluorierungen Radiochemie Späte Funktionalisierung |