Enhanced catalytic performance of copper iodide in 1,2,3-triazole-imidazole hybrid synthesis,and evaluation of their anti-cancer activities along with optical properties besides 1H-tetrazole-imidazole hybrids |
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| Authors: | Ameneh Abolghassemi Fakhree Zarrin Ghasemi Mahdi Rahimi Aziz Shahrisa |
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| Affiliation: | 1. Department of Organic Chemistry and Biochemistry, Faculty of Chemistry, University of Tabriz, Tabriz, Iran;2. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran |
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| Abstract: | New triazole-imidazole and tetrazole-imidazole hybrids were obtained using 2,4,5-triaryl-1-(4-aminophenyl) imidazoles by copper-catalyzedazide-alkyne cycloaddition (CuAAC) and Ugi-azidefour-component(UA-4CRs) process. The synthesis of triazole hybrids was performed in the presence of new copper-incorporated white sandstone nanocatalyst, which was fully characterized by different methods. The construction of newly prepared hybrids was confirmed by spectroscopic techniques. Some of these compounds were evaluated for their anti-cancer properties against MCF-7 cancer cell lines. The absorption and emission parameters of the triazole- and tetrazole-substituted imidazoles were also investigated and compared with each other. |
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| Keywords: | hybrids imidazole nanocatalyst tetrazole triazole |
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