Asymmetric Transformation Driven by Confinement and Self-Release in Single-Layered Porous Nanosheets |
| |
| Authors: | Dr Bo Sun Dr Bowen Shen Akio Urushima Dr Xin Liu Xiaopeng Feng Prof Eiji Yashima Prof Myongsoo Lee |
| |
| Institution: | 1. State Key Laboratory for Supramolecular Strucuture and Materials, College of Chemistry, Jilin University, Changchun, 130012 China;2. Department of Chemistry, Fudan University, Shanghai, 200438 China;3. Department of Molecular and Macromolecular Chemistry, Graduate School of Engineering, Nagoya University, Nagoya, 464-8603 Japan |
| |
| Abstract: | Reported here is the use of single-layered, chiral porous sheets with induced pore chirality for repeatable asymmetric transformations and self-separation without the need for chiral catalysts or chiral auxiliaries. The asymmetric induction is driven by chiral fixation of absorbed achiral substrates inside the chiral pores for transformation into enantiopure products with enantioselectivities of greater than 99 % ee. When the conversion is completed, the products are spontaneously separated out of the pores, enabling the porous sheets to perform repeated cycles of converting achiral substrates into chiral products for release without compromising pore performance. Confinement of achiral substrates into two-dimensional chiral porous materials provides access to a highly efficient alternative to current asymmetric synthesis methodologies. |
| |
| Keywords: | asymmetric synthesis chirality macrocycles materials chemistry porous materials |
|
|
