General Paradigm in Photoredox Nickel-Catalyzed Cross-Coupling Allows for Light-Free Access to Reactivity |
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Authors: | Rui Sun Dr Yangzhong Qin Prof Dr Daniel G Nocera |
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Institution: | Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford St., Cambridge, MA, 02138 USA |
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Abstract: | Self-sustained NiI/III cycles are established as a potentially general paradigm in photoredox Ni-catalyzed carbon–heteroatom cross-coupling reactions through a strategy that allows us to recapitulate photoredox-like reactivity in the absence of light across a wide range of substrates in the amination, etherification, and esterification of aryl bromides, the latter of which has remained, hitherto, elusive under thermal Ni catalysis. Moreover, the accessibility of esterification in the absence of light is especially notable because previous mechanistic studies on this transformation under photoredox conditions have unanimously invoked energy-transfer-mediated pathways. |
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Keywords: | cross-coupling green chemistry photoredox catalysis sustainable chemistry transition metals |
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