Synthesis and antimicrobial evaluation of coordination compounds containing 2,2′-bis(3-aminopyridyl) diselenide as ligand |
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| Authors: | Renne de Sousa Dias Rodrigo Cervo Fallon dos Santos Siqueira Marli Matiko Anraku de Campos Ernesto Schulz Lang Bárbara Tirloni Ricardo Frederico Schumacher Roberta Cargnelutti |
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| Institution: | 1. Departamento de Química, Laboratório de Materiais Inorgânicos, Universidade Federal de Santa Maria, Santa Maria, RS, 97105–900 Brazil;2. Programa de Pós-graduação em Ciências Farmacêuticas, Departamento de Análises Clínicas e Toxicológicas, Universidade Federal de Santa Maria, Santa Maria, RS, 97105–900 Brazil |
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| Abstract: | The reaction between 2,2′-bis(3-aminopyridyl) diselenide (L) and metal transition salts results in the formation of molecular or cluster complexes. The structural elucidation of the synthesized complexes CuCl2(L)] ( 1 ), Cu(3-NH2PySeO2)2]·2H2O ( 2 ), Cu4(3-NH2PySe)4]·dimethylformamide ( 3 ), CoCl2(L)] ( 4 ), ZnCl2(L)] ( 5 ), and Ag6(3-NH2PySe)6] ( 6 ) demonstrates the coordination of nitrogen atoms to CuII, CoII, and ZnII, and that of the selenium atoms to CuI and AgI, which agrees with Pearson’s hard and soft acids and bases (HSAB) theory. Furthermore, the oxidation of selenium with the formation of 3-aminopyridylseleninate 3-NH2PySeO2]? bonded to the copper atom was observed in complex 2 . The antimicrobial action of complexes 1 , 2 , 4 , and 5 was evaluated against Mycobacterium fortuitum, Mycobacterium massiliense, and Mycobacterium abscessus. It was observed that all these complexes have potential antimicrobial activity compared with the free ligand and metal salts used in the synthesis. |
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| Keywords: | antimicrobial evaluation crystalline structure metal complexes selenium |
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