Rhodium(III)-Catalyzed Asymmetric Access to Spirocycles through C−H Activation and Axial-to-Central Chirality Transfer |
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| Authors: | Dr Lingheng Kong Xi Han Song Liu Yun Zou Prof Dr Yu Lan Prof Dr Xingwei Li |
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| Institution: | 1. School of Chemistry and Chemical Engineering, Shannxi Normal University, Xi'an, 710119 China;2. School of Chemistry and Chemical Engineering, Chongqing University, Chongqing, 400030 China |
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| Abstract: | Axial-to-central chirality transfer is an important strategy to construct chiral centers, where the axially chiral reagents are mostly limited to atropomerically stable ones. Reported herein is a RhIII-catalyzed enantioselective spiroannulative synthesis of nitrones. The coupling proceeds via C−H arylation to give an atropomerically metastable biaryl, followed by intramolecular dearomative trapping under oxidative conditions with high degree of chirality transfer. |
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| Keywords: | C-H-Aktivierung Chiralitätstransfer Nitrone Rhodium Spirocyclen |
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