Reduced graphene oxide supported copper oxide nanocomposites: An efficient heterogeneous and reusable catalyst for the synthesis of ynones, 1,3-diynes and 1,5-benzodiazepines in one-pot under sustainable reaction conditions |
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Authors: | Rajib Sarkar Ajay Gupta Ramen Jamatia Amarta Kumar Pal |
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Institution: | Department of Chemistry, Centre for Advanced Studies, North-Eastern Hill University, Shillong, 793022 India |
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Abstract: | A greener and efficient method for the synthesis of ynones and 1,3-diynes using copper oxide nanoparticles (CuONPs) doped reduced graphene oxide (CuO@rGO) catalyst under palladium, ligand and solvent free conditions have been developed. The catalyst was subsequently utilized for the synthesis of biologically active 1,5-benzodiazepines in one pot via sequential addition of acyl chlorides, terminal alkynes and o-phenylenediamines. The methodology initially involves in situ formation of ynones which react with o-phenylenediamines in presence of ethanol to afford a wide variety of benzodiazepines. Mild reaction conditions, good to an excellent yield of the products, cheap and recyclable catalyst make this methodology environmentally benign and sustainable. |
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Keywords: | 1 5-benzodiazepines cross-coupling one-pot synthesis CuO@rGO nanoparticles homo-coupling ynones |
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