Nickel-Catalyzed Asymmetric Reductive 1,2-Carboamination of Unactivated Alkenes |
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| Authors: | Jun He Yuhang Xue Bo Han Chunzhu Zhang Dr You Wang Prof Shaolin Zhu |
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| Institution: | 1. State Key Laboratory of Coordination Chemistry, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093 China;2. State Key Laboratory of Coordination Chemistry, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093 China
These authors contributed equally to this work. |
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| Abstract: | Starting from diverse alkene-tethered aryl iodides and O-benzoyl-hydroxylamines, the enantioselective reductive cross-electrophilic 1,2-carboamination of unactivated alkenes was achieved using a chiral pyrox/nickel complex as the catalyst. This mild, modular, and practical protocol provides rapid access to a variety of β-chiral amines with an enantioenriched aryl-substituted quaternary carbon center in good yields and with excellent enantioselectivities. This process reveals a complementary regioselectivity when compared to Pd and Cu catalysis. |
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| Keywords: | Alkene Asymmetrische Katalyse Carboaminierung Nickel Synthesemethoden |
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