Near-Infrared Light Triggered-Release in Deep Brain Regions Using Ultra-photosensitive Nanovesicles |
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| Authors: | Dr Hejian Xiong Dr Xiuying Li Peiyuan Kang John Perish Dr Frederik Neuhaus Dr Jonathan E Ploski Dr Sven Kroener Maria O Ogunyankin Jeong Eun Shin Dr Joseph A Zasadzinski Dr Hui Wang Dr Paul A Slesinger Dr Andreas Zumbuehl Dr Zhenpeng Qin |
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| Institution: | 1. Department of Mechanical Engineering, The University of Texas at Dallas, Richardson, TX, 75080 USA;2. School of Behavioral and Brain Sciences, The University of Texas at Dallas, Richardson, TX, 75080 USA;3. National Centre of Competence in Research in Chemical Biology, 30 quai Ernest Ansermet, 1211 Geneva 4, Switzerland;4. Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN, 55455 USA;5. Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital/Harvard Medical School, Charlestown, MA, 02129 USA;6. Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, 10029-5674 USA;7. Acthera Therapeutics Ltd., Peter Merian-Str. 45, 4052 Basel, Switzerland |
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| Abstract: | Remote and minimally-invasive modulation of biological systems with light has transformed modern biology and neuroscience. However, light absorption and scattering significantly prevents penetration to deep brain regions. Herein, we describe the use of gold-coated mechanoresponsive nanovesicles, which consist of liposomes made from the artificial phospholipid Rad-PC-Rad as a tool for the delivery of bioactive molecules into brain tissue. Near-infrared picosecond laser pulses activated the gold-coating on the surface of nanovesicles, creating nanomechanical stress and leading to near-complete vesicle cargo release in sub-seconds. Compared to natural phospholipid liposomes, the photo-release was possible at 40 times lower laser energy. This high photosensitivity enables photorelease of molecules down to a depth of 4 mm in mouse brain. This promising tool provides a versatile platform to optically release functional molecules to modulate brain circuits. |
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| Keywords: | brain gold shell mechanoresponsive vesicles near-infrared light uncaging |
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