Cooperative Ni/Cu-Catalyzed Asymmetric Propargylic Alkylation of Aldimine Esters |
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| Authors: | Lingzi Peng Zhuozhuo He Xianghong Xu Prof Dr Chang Guo |
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| Institution: | Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, 230026 China |
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| Abstract: | A novel Ni/Cu dual catalysis gives rise to fundamentally new cooperative reactivity and enables the regio- and enantioselective propargylic alkylation reaction. A diverse set of α-quaternary propargylated amino ester derivatives were synthesized in good yields with excellent enantioselectivity (up to 99 % ee). This work highlights the power of cooperative catalysis, which can be expected to have broad implications in homogeneous catalysis beyond the highly valuable synthetic intermediates. |
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| Keywords: | asymmetric catalysis chiral amine esters dual catalysis homogeneous catalysis propargylation |
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