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Time-Dependent Photodynamic Therapy for Multiple Targets: A Highly Efficient AIE-Active Photosensitizer for Selective Bacterial Elimination and Cancer Cell Ablation |
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| Authors: | Qiyao Li Dr. Ying Li Tianliang Min Junyi Gong Dr. Lili Du Prof. David Lee Phillips Junkai Liu Dr. Jacky W. Y. Lam Dr. Herman H. Y. Sung Prof. Ian D. Williams Dr. Ryan T. K. Kwok Prof. Chun Loong Ho Prof. Kai Li Prof. Jianguo Wang Prof. Ben Zhong Tang |
| Affiliation: | 1. Department of Chemistry, Hong Kong Branch of Chinese National Engineering., Research Center for Tissue Restoration and Reconstruction, Institute of Molecular Functional Materials, State Key Laboratory of Molecular Nanoscience, Division of Life Science and Department of Chemical and Biomedical Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China;2. Center for AIE Research, College of Materials Science and Engineering, Shenzhen University, Shenzhen, 518060 China These authors contributed equally to this work.;3. Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, Guangdong, 518055 China These authors contributed equally to this work.;4. Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, China;5. Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, Guangdong, 518055 China;6. College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot, 010021 China |
| Abstract: | Pathogen infections and cancer are two major human health problems. Herein, we report the synthesis of an organic salt photosensitizer (PS), called 4TPA-BQ, by a one-step reaction. 4TPA-BQ presents aggregation-induced emission features. Owing to the aggregation-induced reactive oxygen species generated and a sufficiently small ΔEST, 4TPA-BQ shows a satisfactorily high 1O2 generation efficiency of 97.8 %. In vitro and in vivo experiments confirmed that 4TPA-BQ exhibited potent photodynamic antibacterial performance against ampicillin-resistant Escherichia coli with good biocompatibility in a short time (15 minutes). When the incubation duration persisted long enough (12 hours), cancer cells were ablated efficiently, leaving normal cells essentially unaffected. This is the first reported time-dependent fluorescence-guided photodynamic therapy in one individual PS, which achieves ordered and multiple targeting simply by varying the external conditions. 4TPA-BQ reveals new design principles for the implementation of efficient PSs in clinical applications. |
| Keywords: | Aggregationsinduzierte Emission Anion-π-Wechselwirkungen Antibakterielle Wirkstoffe Krebszellen Multiples Targeting |