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Spectroscopic and theoretical studies on Cr (III), Mn (II) and Cu (II) complexes of hydrazone derived from picolinic hydrazide and O-vanillin and evaluation of biological potency |
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| Authors: | Gamil A.A. Al-Hazmi Khlood S. Abou-Melha Nashwa M. El-Metwaly Ismail Althagafi Fathy Shaaban Marwa G. Elghalban Mohammed M. El-Gamil |
| Affiliation: | 1. Chemistry Department, Faculty of Science, King Khalid University, P.O. Box 9004, Abha, Saudi Arabia Chemistry Department, Faculty of Applied Sciences, Taiz University, P.O. Box 82, Taiz, Yemen;2. Chemistry Department, Faculty of Science, King Khalid University, P.O. Box 9004, Abha, Saudi Arabia;3. Department of Chemistry, Faculty of applied science, Umm-Al-Qura University, Makkah, Saudi Arabia;4. Custodian of two holy mosques Institute for Hajj and Umrah Research, Umm-Al-Qura University, Makkah, Saudi Arabia;5. Department of Chemistry, Faculty of applied science, Umm-Al-Qura University, Makkah, Saudi Arabia Department of Chemistry, Faculty of Science, Mansoura University, El-Gomhoria Street, Egypt;6. Department of Toxic and Narcotic Drug, Forensic Medicine, Mansoura Laboratory, Medico-legal Organization,, Ministry of Justice, Egypt |
| Abstract: | Trivalent Cr (III) and divalent of both Mn (II) and Cu (II) complexes containing hydrazone ligands derived from the condensation of picolinohydrazide with O-vanillin were synthesised and characterized by elemental analysis, spectral and magnetic measurements. The suggested octahedral structures were confirmed by applying DFT optimization and conformational studies. The thermal decomposition behaviour of Mn (II) complex is discussed. The evaluation of kinetic parameters (Ea, A, ∆H, ∆S and ∆G) of all thermal degradation stages have been evaluated using Coats-Redfern and Horowitz-Metzger approaches. The band gap results suggested that these complexes are semi-conductors and lie in same range of highly efficient photovoltaic materials. Antibacterial studies showed that higher activity of complexes than of ligands. Assay on the antioxidant activity (DPPH and SOD) of the above complexes revealed the high SOD-activity of Mn (II) complex and high DPPH-activity for ligand. |
| Keywords: | antioxidant activity Hydrazone molecular docking spectral characterization thermal degradation |