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NHC-Stabilized Iridium Nanoparticles as Catalysts in Hydrogen Isotope Exchange Reactions of Anilines |
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| Authors: | Mégane Valero Dr. Donia Bouzouita Dr. Alberto Palazzolo Dr. Jens Atzrodt Dr. Christophe Dugave Dr. Simon Tricard Dr. Sophie Feuillastre Dr. Grégory Pieters Dr. Bruno Chaudret Dr. Volker Derdau |
| Affiliation: | 1. Sanofi-Aventis (Deutschland) GmbH, R&D, Integrated Drug Discovery, Industriepark Höchst, 65926 Frankfurt am Main, Germany These authors contributed equally to this work.;2. LPCNO, Laboratoire de Physique et Chimie de Nano-Objets, UMR, 5215 INSA-CNRS-UPS, Institut National des Sciences Appliquées, 135, Avenue de Rangueil, 31077 Toulouse, France These authors contributed equally to this work.;3. SCBM, JOLIOT Institute, CEA, Université Paris-Saclay, 91191 Gif-sur-Yvette, France These authors contributed equally to this work.;4. Sanofi-Aventis (Deutschland) GmbH, R&D, Integrated Drug Discovery, Industriepark Höchst, 65926 Frankfurt am Main, Germany;5. SCBM, JOLIOT Institute, CEA, Université Paris-Saclay, 91191 Gif-sur-Yvette, France;6. LPCNO, Laboratoire de Physique et Chimie de Nano-Objets, UMR, 5215 INSA-CNRS-UPS, Institut National des Sciences Appliquées, 135, Avenue de Rangueil, 31077 Toulouse, France |
| Abstract: | The preparation of N-heterocyclic carbene-stabilized iridium nanoparticles and their application in hydrogen isotope exchange reactions is reported. These air-stable and easy-to-handle iridium nanoparticles showed a unique catalytic activity, allowing selective and efficient hydrogen isotope incorporation on anilines using D2 or T2 as isotopic source. The usefulness of this transformation has been demonstrated by the deuterium and tritium labeling of diverse complex pharmaceuticals. |
| Keywords: | C-H-Aktivierung C-H-Funktionalisierung Heterogene Katalyse Iridium-Nanopartikel Wasserstoff-Isotopenaustausch |