Green synthesis of Fe3O4/ZnO magnetic core-shell nanoparticles by Petasites hybridus rhizome water extract and their application for the synthesis of pyran derivatives: Investigation of antioxidant and antimicrobial activity |
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| Authors: | Mahboubeh Ghasemian Dazmiri Heshmatollah Alinezhad Zinatossadat Hossaini Ahmad R Bekhradnia |
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| Institution: | 1. Facualty of Chemistry, University of Mazandaran, Babolsar, Iran;2. Department of Chemistry, Qaemshahr Branch, Islamic Azad University, Qaemshahr, Iran;3. Pharmaceutical Sciences Research Center, Department of Medicinal Chemistry, Mazandaran University of Medical Sciences, Sari, Iran
Department of Chemistry and Biochemistry, Montana State University, Bozeman, MT, 59717 USA |
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| Abstract: | In this research, Fe3O4/ZnO magnetic core-shell nanoparticles (Fe3O4/ZnO MCNPs) were synthesized through a green method using Petasites hybridus rhizome water extract as a reducing and stabilizing agent. The morphology and size of the Fe3O4/ZnO MCNPs was identified by X-ray diffraction, scanning electron microscopy, and Energy-dispersive X-ray spectroscopy (EDX) analysis. The catalytic activity of the Fe3O4/ZnO MCNPs was evaluated in the efficient and green preparation of pyran derivatives in excellent yield using three-component reactions of dimedone, aldehydes, and malononitrile in ethanol at room temperature. The ability of some synthesized compounds to scavenge the 2,2-diphenyl-1-picrylhydrazyl radical was measured and the results proved this observation. Moreover, the antimicrobial activity of some synthesized compounds was proved by employing the disk diffusion test on Gram-positive and Gram-negative bacteria. The results for the disk diffusion test showed that compounds ( 4c, 4d, 4f and 4g ) prevented bacterial growth. |
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| Keywords: | Dimedone Fe3O4/ZnO core-shell nanoparticles Gram-positive and Gram-negative bacteria multicomponent reaction 2 2-diphenyl-1-picrylhydrazyl |
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