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Aqueous Ring-Opening Polymerization-Induced Self-Assembly (ROPISA) of N-Carboxyanhydrides |
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| Authors: | Dr. Chloé Grazon Pedro Salas-Ambrosio Emmanuel Ibarboure Alix Buol Dr. Elisabeth Garanger Prof. Mark W. Grinstaff Prof. Sébastien Lecommandoux Dr. Colin Bonduelle |
| Affiliation: | 1. CNRS, Bordeaux INP, LCPO, UMR 5629, Univ. Bordeaux, 33600 Pessac, France;2. Departments of Chemistry and Biomedical Engineering, Boston University, Boston, MA, USA |
| Abstract: | Reported here is the first aqueous ring-opening polymerization (ROP) of N-carboxyanhydrides (NCAs) using α-amino-poly(ethylene oxide) as a macroinitiator to protect the NCA monomers from hydrolysis through spontaneous in situ self-assembly (ISA). This ROPISA process affords well-defined amphiphilic diblock copolymers that simultaneously form original needle-like nanoparticles. |
| Keywords: | Amphiphile Polymerisation Selbstorganisation Synthesemethoden Wasser |