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Synthesis,characterization, antifungal and antibacterial activities evaluation of copper (II), zinc (II) and cadmium (II) chloride and bromide complexes with new (E)-1-(3,4-dimethoxybenzylidene)-4-methylthiosemicarbazone ligand |
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| Authors: | Amani Jaafar Adeline Fix-Tailler Najwa Mansour Magali Allain Wassim N. Shebaby Wissam H. Faour Sima Tokajian Abdelkrim El-Ghayoury Daoud Naoufal Jean-Philippe Bouchara Gérald Larcher Ghassan Ibrahim |
| Affiliation: | 1. Inorganic and Organometallic Coordination Chemistry laboratory, Lebanese University, Faculty of Science, Section I, Hadath, Lebanon Groupe d’Etude des Interactions Hôte-Pathogène, UPRES-EA 3142, SFR 132, Université d'Angers, Institut de Biologie en Santé, CHU, 4 rue Larrey, Angers cedex, 49933 France Contribution: Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Validation, Visualization;2. Groupe d’Etude des Interactions Hôte-Pathogène, UPRES-EA 3142, SFR 132, Université d'Angers, Institut de Biologie en Santé, CHU, 4 rue Larrey, Angers cedex, 49933 France Contribution: Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Validation, Visualization;3. Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, PO Box 36, Byblos, Lebanon Contribution: Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Validation, Visualization;4. Laboratoire MOLTECH-Anjou, UMR CNRS 6200, UNIV Angers, SFR MATRIX, 2 Bd Lavoisier, Angers Cedex, 49045 France Contribution: Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Software, Validation, Visualization;5. Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, PO Box 36, Byblos, Lebanon Contribution: Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Validation, Visualization;6. Gilbert & Rose-Marie Chagoury School of Medicine, Lebanese American University, PO Box 36, Byblos, Lebanon;7. Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, PO Box 36, Byblos, Lebanon Contribution: Data curation, Formal analysis, Methodology, Project administration, Resources, Validation, Visualization;8. Laboratoire MOLTECH-Anjou, UMR CNRS 6200, UNIV Angers, SFR MATRIX, 2 Bd Lavoisier, Angers Cedex, 49045 France Contribution: Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Validation, Visualization;9. Inorganic and Organometallic Coordination Chemistry laboratory, Lebanese University, Faculty of Science, Section I, Hadath, Lebanon Contribution: Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization;10. Groupe d’Etude des Interactions Hôte-Pathogène, UPRES-EA 3142, SFR 132, Université d'Angers, Institut de Biologie en Santé, CHU, 4 rue Larrey, Angers cedex, 49933 France Contribution: Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization;11. Inorganic and Organometallic Coordination Chemistry laboratory, Lebanese University, Faculty of Science, Section I, Hadath, Lebanon |
| Abstract: | The reactions of Cu (II), Zn (II) and Cd (II) chloride or bromide with (E)-1-(3,4-dimethoxybenzylidene)-4-methylthiosemicarbazone (MTSVT) lead to the formation of new complexes. They were characterized by spectroscopic studies: IR, 1H and 13C NMR. The crystal structures of the compounds [MTSVT] ( L ), [ZnBr2(MTSVT)2] ( 2 ), [CdCl2(MTSVT)2] ( 3 ) and [CdBr2(MTSVT)2.H2O] ( 4 ) were determined by X-ray diffraction. For complexes 2 – 4 , the ion is coordinated through the sulfur atom. All compounds were tested for their antifungal activity against human pathogenic fungi Candida albicans and Aspergillus fumigatus, and for their antibacterial activity against Gram (+) Bacillus subtilis and Enterococcus faecalis as well as against Gram (−) bacteria such as Paracoccus yeei and Acinetobacter baumanii. The results indicated that the metal complexes exhibited a marked enhancement in antibacterial activity compared with the parent Schiff base. |
| Keywords: | (E)-1-(3,4-dimethoxybenzylidenemethylthiosemicarbazone antibacterial activity antifungal activity crystal structure Zn and Cd complexes |