Highly Regio-, Diastereo-, and Enantioselective Synthesis of Tetrahydroazepines and Benzo[b]oxepines through Palladium-Catalyzed [4+3] Cycloaddition Reactions |
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Authors: | Prof. Dr. Barry M. Trost Dr. Zhijun Zuo |
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Affiliation: | Department of Chemistry, Stanford University, Stanford, CA, 94305-5080 USA |
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Abstract: | A novel Pd0-catalyzed asymmetric [4+3] annulation reaction of two readily accessible starting materials has been developed for building seven-membered heterocyclic architectures. The potential [3+2] side pathway could be suppressed though fine tuning of the conditions. A broad scope of cycloaddition donors and acceptors participated in the transformation with excellent chemo-, regio-, diastereo-, and enantioselectivtities, leading to valuable tetrahydroazepines and benzo[b]oxepines. |
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Keywords: | Anellierungen Asymmetrische Katalyse Heterocyclen Palladium |
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