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Non-Diazo C?H Insertion Approach to Cyclobutanones through Oxidative Gold Catalysis |
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| Authors: | Dr Zhitong Zheng Dr Youliang Wang Xu Ma Dr Yuxue Li Prof?Dr Liming Zhang |
| Institution: | 1. Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA, 93106 USA;2. Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA, 93106 USA
Current address: School of Chemistry, Xi'an Jiaotong University, Xi'an, 710049 P. R. China These authors contributed equally to this work.;3. CAS Key Laboratory of Energy Regulation Materials, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, 200032 P. R. China |
| Abstract: | Cyclobutanones are synthetically versatile compounds that often require extensive effort to access. Herein, we report a facile synthesis of cyclobutanones based on the C(sp3)?H insertion chemistry of oxidatively generated gold carbenes. Various cyclobutanones were obtained in synthetically useful yields from substrates with minimal structural prefunctionalization. This discovery reveals new synthetic utilities of gold-catalyzed oxidative transformations of alkynones. |
| Keywords: | catalysis C?H insertion cyclobutanone gold carbene oxidation |