To Sandwich Technetium: Highly Functionalized Bis-Arene Complexes [99mTc(η6-arene)2]+ Directly from Water and [99mTcO4]? |
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Authors: | Dr Qaisar Nadeem Dr Giuseppe Meola Dr Henrik Braband Robin Bolliger Dr Olivier Blacque Daniel Hernández-Valdés Prof?Dr Roger Alberto |
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Institution: | Department of Chemistry, University of Zurich, Winterthurerstr. 190, 8057 Zurich, Switzerland |
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Abstract: | The labeling of (bio)molecules with metallic radionuclides such as 99mTc demands conjugated, multidentate chelators. However, this is not always necessary since phenyl rings can directly serve as integrated, organometallic ligands. Bis-arene sandwich complexes are generally prepared by the Fischer–Hafner reaction. In extension of this, we show that 99mTc(η6-C6R6)2]+-type complexes are directly accessible from water and 99mTcO4]?, even using arenes incompatible with Fischer–Hafner conditions. To unambiguously confirm the nature of these unprecedented 99mTc complexes, their rhenium homologous have been prepared by substituting naphthalene ligands in Re(η6-C10H8)2]+ with the corresponding phenyl groups. The ease with which highly stable 99mTc(η6-C6R6)2]+ complexes are formed under standard labeling conditions enables a multitude of new potential imaging agents based on commercial pharmaceuticals or lead structures. |
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Keywords: | Molekulare Bildgebung Rhenium Sandwich-Komplexe Screening Technetium |
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