Antimicrobial,antioxidant and antitumor activities of Nano-Structure Eu (III) and La (III) complexes with nitrogen donor tridentate ligands

Nano structure metal complexes of Eu (III) and La (III) with two different nitrogen donor tridentate ligands: N-(2-Aminoethyl)-1,3-propanediamine “AEPD = L1” and 1-(2-Aminoethyl)piperazine “AEPz = L2” , were prepared. All synthesized compounds were identified and confirmed by elemental analyses, molar conductivity and spectral analyses (UV–Visible, IR and mass). Conductance measurement indicates that all the complexes are non-electrolytic in nature and the complexes were isolated in 1:1 molar ratio (metal: ligand). Thermal decomposition profiles were consistent with the proposed formulations. The ligands behave as a tridentate ligand through three nitrogen centers of donation. The nano-size was investigated by using transmission electron microscopy (TEM). The geometric structure properties were analyzed using density functional theory (DFT) for ligands and their Lanthanum (III) complexes. The complexes were screened against some bacteria strains, hepatocellular cell line and diphenylhydrazine free radical. The molecular docking active sites interactions were evaluated.