Synthesis of pyrimidine derivatives via multicomponent reaction catalyzed by ferric chloride |
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| Authors: | Liang Xian Cui-Ting Ma Ying-Gen Ouyang Jia-Qi Di Zhan-Hui Zhang |
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| Affiliation: | 1. Department of Radiochemistry, China Institute of Atomic Energy, Beijing, 102413 China;2. Hebei Key Laboratory of Organic Functional Molecules, National Demonstration Center for Experimental Chemistry Education, College of Chemistry and Material Science, Hebei Normal University, Shijiazhuang, 050024 China |
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| Abstract: | An eco-friendly and practical approach was developed for the synthesis of pyrimidine derivatives via a one-pot, three-component coupling reaction of commercially available aldehydes, alkynes, and indazole3/triazole catalyzed by ferric chloride with good to excellent yields. The advantages of this method include environmentally friendly catalyst, easily available materials, and ease of product isolation. |
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| Keywords: | ferric chloride heterocycle multicomponent reaction pyrimidine derivatives |
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