|
|||||
|
|
Self-Amplified Photodynamic Therapy through the 1O2-Mediated Internalization of Photosensitizers from a Ppa-Bearing Block Copolymer |
|
| Authors: | Zhiyong Liu Tianye Cao Yudong Xue Mengting Li Mengsi Wu Prof Jonathan W Engle Prof Qianjun He Prof Weibo Cai Prof Minbo Lan Prof Weian Zhang |
| Institution: | 1. Shanghai Key Laboratory of Functional Materials Chemistry, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237 China
These authors contributed equally to this work.;2. Departments of Radiology and Medical Physics, University of Wisconsin-Madison, Madison, WI, 53705 USA Guangdong Provincial Key Laboratory of Biomedical Measurements and Ultrasound Imaging, National-Regional Key Technology Engineering Laboratory for, Medical Ultrasound, School of Biomedical Engineering, Health Science Center, Shenzhen University, No. 1066 Xueyuan Road, Nanshan District, Shenzhen, 518060 Guangdong, China These authors contributed equally to this work.;3. Shanghai Key Laboratory of Functional Materials Chemistry, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237 China;4. Departments of Radiology and Medical Physics, University of Wisconsin-Madison, Madison, WI, 53705 USA;5. Guangdong Provincial Key Laboratory of Biomedical Measurements and Ultrasound Imaging, National-Regional Key Technology Engineering Laboratory for, Medical Ultrasound, School of Biomedical Engineering, Health Science Center, Shenzhen University, No. 1066 Xueyuan Road, Nanshan District, Shenzhen, 518060 Guangdong, China |
| Abstract: | Nanocarriers are employed to deliver photosensitizers for photodynamic therapy (PDT) through the enhanced penetration and retention effect, but disadvantages including the premature leakage and non-selective release of photosensitizers still exist. Herein, we report a 1O2-responsive block copolymer (POEGMA-b-P(MAA-co-VSPpaMA) to enhance PDT via the controllable release of photosensitizers. Once nanoparticles formed by the block copolymer have accumulated in a tumor and have been taken up by cancer cells, pyropheophorbide a (Ppa) could be controllably released by singlet oxygen (1O2) generated by light irradiation, enhancing the photosensitization. This was demonstrated by confocal laser scanning microscopy and in vivo fluorescence imaging. The 1O2-responsiveness of POEGMA-b-P(MAA-co-VSPpaMA) block copolymer enabled the realization of self-amplified photodynamic therapy by the regulation of Ppa release using NIR illumination. This may provide a new insight into the design of precise PDT. |
| Keywords: | Blockcopolymere Wirkstoffabgabe Photodynamische Therapie Reaktive Sauerstoffspezies Selbstverstärkung |