Tunable DNA Origami Motors Translocate Ballistically Over μm Distances at nm/s Speeds |
| |
Authors: | Alisina Bazrafshan Travis A Meyer Hanquan Su Joshua M Brockman Aaron T Blanchard Selma Piranej Yuxin Duan Yonggang Ke Khalid Salaita |
| |
Institution: | 1. Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, GA, 30322 USA;2. Wallace H. Coulter Department of Biomedical Engineering, Georgia, Institute of Technology and Emory University, Atlanta, GA, 30322 USA |
| |
Abstract: | Inspired by biological motor proteins, that efficiently convert chemical fuel to unidirectional motion, there has been considerable interest in developing synthetic analogues. Among the synthetic motors created thus far, DNA motors that undertake discrete steps on RNA tracks have shown the greatest promise. Nonetheless, DNA nanomotors lack intrinsic directionality, are low speed and take a limited number of steps prior to stalling or dissociation. Herein, we report the first example of a highly tunable DNA origami motor that moves linearly over micron distances at an average speed of 40 nm/min. Importantly, nanomotors move unidirectionally without intervention through an external force field or a patterned track. Because DNA origami enables precise testing of nanoscale structure-function relationships, we were able to experimentally study the role of motor shape, chassis flexibility, leg distribution, and total number of legs in tuning performance. An anisotropic rigid chassis coupled with a high density of legs maximizes nanomotor speed and endurance. |
| |
Keywords: | DNA-Motoren DNA-Origami Dynamische DNA-Nanotechnologie Fluoreszenzmikroskopie Nanomaschinen |
|
|