Copper-Catalyzed Carbonylative Hydroamidation of Styrenes to Branched Amides |
| |
Authors: | Yang Yuan Fu-Peng Wu Claas Schünemann Dr Jens Holz Prof Dr Paul C J Kamer Prof Dr Xiao-Feng Wu |
| |
Institution: | Leibniz-Institut für Katalyse e.V. an der, Universität Rostock, Albert-Einstein-Straße 29a, 18059 Rostock, Germany |
| |
Abstract: | Amides are one of the most ubiquitous functional groups in synthetic and medicinal chemistry. Novel and rapid synthesis of amides remains in high demand. In this communication, a general and efficient procedure for branch-selective hydroamidation of vinylarenes with hydroxyamine derivatives enabled by copper catalysis has been developed for the first time. The reaction proceeds under mild conditions and tolerates a broad range of functional groups. Applying a chiral phosphine ligand, an enantioselective variant of this transformation was achieved, affording a variety of chiral α-amides with excellent enantioselectivities (up to 99 % ee) and high yields. |
| |
Keywords: | amides carbonylation copper enantioselectivity hydroamidation |
|
|