Affiliation: | 1. Chemistry Department, Faculty of Science, Alexandria University, 2 Bagdad street, PO Box 2-Moharrem Beck, Alexandria, 21321 Egypt Contribution: Methodology, Project administration, Supervision;2. Chemistry Department, Faculty of Science, Alexandria University, 2 Bagdad street, PO Box 2-Moharrem Beck, Alexandria, 21321 Egypt Contribution: Formal analysis, Investigation;3. Theoretical Applied Chemistry Unit (TACU), Chemistry Department, Faculty of Science, Tanta University, Tanta, Egypt Contribution: Data curation, Software, Validation;4. Chemistry Department, Faculty of Science, Alexandria University, 2 Bagdad street, PO Box 2-Moharrem Beck, Alexandria, 21321 Egypt Contribution: Formal analysis;5. Chemistry Department, Faculty of Science, Alexandria University, 2 Bagdad street, PO Box 2-Moharrem Beck, Alexandria, 21321 Egypt |
Abstract: | A series of nanometer-sized spherical sulfonamide imine ligands HL 1 -HL 5 and their copper and zinc complexes were synthesized and fully characterized based on elemental analyses, spectroscopic (UV/vis, FT-IR, NMR, EPR, SEM) studies, molar conductance and thermal analyses. Furthermore, computational studies of HL 1 -HL 5 were carried out by the DFT/B3LYP method. TD-DFT, HOMO and LUMO energy values, chemical hardness, electronegativity, electrophilic index, softness, and other parameters were calculated. Screening against several pathogenic microorganisms indicated that HL 1 exhibited high activity against the tested Gram-negative bacteria relative to other analogues and the inhibition activity is greater than the standard Gentamicin. Analogously, HL 2 exhibited high potent activity against the tested Gram-positive bacteria. Copper complexes exhibited a higher potent activity than zinc analogues. Noteworthy, inhibition activity of [Cu ( L 3 )(OAc)] complex is higher than that of the standard Ampicillin. [Cu ( L 2 )(OAc)] complex displayed a similar activity of the standard bactericides and fungicides in use. The complexes showed appreciated values of MIC against bacterial strains: B. subtilis (MIC = 0.4 μg / mL), E. coli and S. pneumonia (MIC = 1.95 μg / mL) and P. aeruginosa (MIC = 7.81 μg / mL). in vitro cytotoxic activities study proved that [Cu ( L 3 )(OAc)] complex exhibited appreciable activity versus (HEPG-2); IC50 = 4.8 μg/ml, while [Cu( L 2 )(OAc)] complex showed a high activity against (MCF-7); IC50 = 6.2 μg/ml. These results could be considered as new findings of promising antitumor candidates for experimental chemotherapy. |