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A Supramolecular-Based Dual-Wavelength Phototherapeutic Agent with Broad-Spectrum Antimicrobial Activity Against Drug-Resistant Bacteria |
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| Authors: | Zhi-Hao Yu Xingshu Li Dr Fugui Xu Xi-Le Hu Dr Jiatao Yan Nahyun Kwon Guo-Rong Chen Dr Tingting Tang Dr Xiaojing Dong Prof Yiyong Mai Prof Daijie Chen Prof Juyoung Yoon Prof Xiao-Peng He Prof He Tian |
| Institution: | 1. Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong RD, Shanghai, 200237 China
These authors contributed equally to this work.;2. Department of Chemistry and Nanoscience, Ewha Womans University, Seoul, 03760 Republic of Korea These authors contributed equally to this work.;3. School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Key Laboratory of Electrical Insulation and Thermal Ageing, Shanghai Jiao Tong University, 800 Dongchuan RD, Shanghai, 200240 China These authors contributed equally to this work.;4. Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong RD, Shanghai, 200237 China;5. Department of Polymer Materials, College of Materials Science and Engineering, Shanghai University, Shanghai, 200444 China;6. Department of Chemistry and Nanoscience, Ewha Womans University, Seoul, 03760 Republic of Korea;7. Shanghai Key Laboratory of Orthopedic Implants, Department of Orthopedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011 China;8. Shanghai Institute of Pharmaceutical Industry, 285 Gebaini RD, Shanghai, 201203 China;9. School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Key Laboratory of Electrical Insulation and Thermal Ageing, Shanghai Jiao Tong University, 800 Dongchuan RD, Shanghai, 200240 China |
| Abstract: | With the ever-increasing threat posed by the multi-drug resistance of bacteria, the development of non-antibiotic agents for the broad-spectrum eradication of clinically prevalent superbugs remains a global challenge. Here, we demonstrate the simple supramolecular self-assembly of structurally defined graphene nanoribbons (GNRs) with a cationic porphyrin (Pp4N) to afford unique one-dimensional wire-like GNR superstructures coated with Pp4N nanoparticles. This Pp4N/GNR nanocomposite displays excellent dual-modal properties with significant reactive-oxygen-species (ROS) production (in photodynamic therapy) and temperature elevation (in photothermal therapy) upon light irradiation at 660 and 808 nm, respectively. This combined approach proved synergistic, providing an impressive antimicrobial effect that led to the complete annihilation of a wide spectrum of Gram-positive, Gram-negative, and drug-resistant bacteria both in vitro and in vivo. The study also unveils the promise of GNRs as a new platform to develop dual-modal antimicrobial agents that are able to overcome antibiotic resistance. |
| Keywords: | Antimikrobielle Aktivität Graphen-Nanobänder Phototherapie Porphyrin Supramolekulare Strukturen |