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Tunable Bidirectional Electroosmotic Flow for Diffusion-Based Separations |
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| Authors: | Vesna Bacheva Dr Federico Paratore Dr Shimon Rubin Dr Govind V Kaigala Prof Moran Bercovici |
| Institution: | 1. Faculty of Mechanical Engineering, Technion—, Israel Institute of Technology, Technion City, 3200003 Haifa, Israel
IBM Research Europe, Säumerstrasse 4, 8803 Rüschlikon, Switzerland These authors contributed equally to this work.;2. Faculty of Mechanical Engineering, Technion—, Israel Institute of Technology, Technion City, 3200003 Haifa, Israel Current address: Department of Electrical and Computer Engineering, University of California San Diego, San Diego, CA, 92093 USA;3. IBM Research Europe, Säumerstrasse 4, 8803 Rüschlikon, Switzerland;4. Faculty of Mechanical Engineering, Technion—, Israel Institute of Technology, Technion City, 3200003 Haifa, Israel |
| Abstract: | We present a new concept for on-chip separation that leverages bidirectional flow, to tune the dispersion regime of molecules and particles. The system can be configured so that low diffusivity species experience a ballistic transport regime and are advected through the chamber, whereas high diffusivity species experience a diffusion dominated regime with zero average velocity and are retained in the chamber. We detail the means of achieving bidirectional electroosmotic flow using an array of alternating current (AC) field-effect electrodes, experimentally demonstrate the separation of particles and antibodies from dyes, and present a theoretical analysis of the system, providing engineering guidelines for its design and operation. |
| Keywords: | diffusion-based separations diffusivity electrokinetics fractionation microfluidics |