Fluoro-Substituted Methyllithium Chemistry: External Quenching Method Using Flow Microreactors |
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| Authors: | Marco Colella Arianna Tota Dr Yusuke Takahashi Ryosuke Higuma Susumu Ishikawa Prof Dr Leonardo Degennaro Prof Dr Renzo Luisi Prof Dr Aiichiro Nagaki |
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| Institution: | 1. Department of Pharmacy—Drug Sciences, Flow Chemistry and Microreactor Technology FLAME-Lab, University of Bari “A. Moro”, Via E. Orabona 4, 70125 Bari, Italy;2. Department of Synthetic and Biological Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto, 615-8510 Japan |
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| Abstract: | The external quenching method based on flow microreactors allows the generation and use of short-lived fluoro-substituted methyllithium reagents, such as fluoromethyllithium, fluoroiodomethyllithium, and fluoroiodostannylmethyllithium. Highly chemoselective reactions have been developed, opening new opportunities in the synthesis of fluorinated molecules using fluorinated organometallics. |
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| Keywords: | amides flow chemistry lithium microreactor reactive intermediates |
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