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Stimuli-Responsive Cycloaurated “OFF-ON” Switchable Anion Transporters |
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| Authors: | Dr Mohamed Fares Dr Xin Wu Deepthi Ramesh Dr William Lewis Prof Paul A Keller Dr Ethan N W Howe Prof Ricardo Pérez-Tomás Prof Philip A Gale |
| Institution: | 1. School of Chemistry, The University of Sydney, Sydney, New South Wales, 2006 Australia
School of Chemistry & Molecular Bioscience, Molecular Horizons, University of Wollongong, Illawarra Health & Medical Research Institute, Wollongong, NSW, 2522 Australia;2. School of Chemistry, The University of Sydney, Sydney, New South Wales, 2006 Australia;3. Faculty of Medicine & Health Sciences, Department of Pathology and Experimental Therapeutics, Cancer Cell Biology Research Group, University of Barcelona, Barcelona, Spain;4. School of Chemistry & Molecular Bioscience, Molecular Horizons, University of Wollongong, Illawarra Health & Medical Research Institute, Wollongong, NSW, 2522 Australia |
| Abstract: | Anion transporters have shown potential application as anti-cancer agents that function by disrupting homeostasis and triggering cell death. In this research article we report switchable anion transport by gold complexes of anion transporters that are “switched on” in situ in the presence of the reducing agent GSH by decomplexation of gold. GSH is found in higher concentrations in tumors than in healthy tissue and hence this approach offers a strategy to target these systems to tumors. |
| Keywords: | anion transport gold complexes molecular switch reduction kinetics supramolecular chemistry |