A Chiral-Label-Free SERS Strategy for the Synchronous Chiral Discrimination and Identification of Small Aromatic Molecules |
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| Authors: | Dr Yue Wang Xueqi Zhao Dr Zhi Yu Prof Zhangrun Xu Prof Bing Zhao Prof Yukihiro Ozaki |
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| Institution: | 1. Department of Chemistry, College of Sciences, Northeastern University, Shenyang, 110819 P. R. China;2. State Key Laboratory of Applied Optics, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun, 130033 P. R. China;3. State Key Laboratory of Supramolecular Structure and Materials, Jilin University, 2699 Qianjin Street, Changchun, 130012 P. R. China;4. Department of Chemistry, School of Science and Technology, Kwansei Gakuin University, Sanda, Hyogo, 669-1337 Japan |
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| Abstract: | A versatile and robust chiral discrimination strategy for small aromatic compounds is of significant importance in multidisciplinary fields. However, most current methods lack either the sufficient sensitivity for recognizing the chirality of the target molecules or their molecular specificity information. We have developed a versatile and chiral-label-free surface-enhanced Raman scattering (SERS)-based chiral discrimination sensing system for small aromatic molecules, where the molecular structural specificity and enantioselectivity can be given synchronously in a single SERS spectrum. More than 10 types of chiral aromatic molecules were successfully identified by using this system. This work has enormous potential for recognizing chiral products effectively in sophisticated systems, especially in the fields of chiral synthesis and chiral catalysis. |
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| Keywords: | charge transfer small aromatic molecules SERS chiral discrimination |
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