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Enantiomorphic Microvortex-Enabled Supramolecular Sensing of Racemic Amino Acids by Using Achiral Building Blocks |
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| Authors: | Yike Li Dr Chao Liu Xuan Bai Dr Fei Tian Prof Guoqing Hu Prof Jiashu Sun |
| Institution: | 1. CAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190 China
School of Future Technology, University of Chinese Academy of Sciences, Beijing, 100149 China These authors contributed equally to this work.;2. School of Future Technology, University of Chinese Academy of Sciences, Beijing, 100149 China The State Key Laboratory of Nonlinear Mechanics, Institute of Mechanics, Chinese Academy of Sciences, Beijing, 100190 China These authors contributed equally to this work.;3. CAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190 China School of Future Technology, University of Chinese Academy of Sciences, Beijing, 100149 China;4. Department of Engineering Mechanics, Zhejiang University, Hangzhou, 310027 China;5. CAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190 China |
| Abstract: | Chiral analysis of bioactive molecules is of increasing significance in chemical and life sciences. However, the quantitative detection of a racemic mixture of enantiomers is a challenging task, which relies on complicated and time-consuming multiple steps of chiral derivatization, chiral separation, and spectroscopic measurement. Herein, we show that, without the use of chiral molecules or pretreatment steps, the co-assembly of amino acids with achiral TPPS4 monomers controlled by enantiomorphic microvortices allows quantitative detection of racemic or enantiomeric amino acids, through analysis of the sign and magnitude of supramolecular chirality in different outlets of a microfluidic platform. A model demonstrates that chiral microvortices can induce an initial chiral bias by bending the sheet structure, resulting in supramolecular self-assembly of TPPS4 and amino acids of compatible chirality by the self-sorting. This sensing system may find versatile applications in chiral sensing. |
| Keywords: | Chiralität Quantitative Analyse Enantiomorphe Mikrowirbel Racemische Aminosäuren Supramoleküle |