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Multifunctional AuI-based AIEgens: Manipulating Molecular Structures and Boosting Specific Cancer Cell Imaging and Theranostics |
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| Authors: | Jing Zhang Dr Hang Zou Jinping Lei Benzhao He Xuewen He Dr Herman H Y Sung Dr Ryan T K Kwok Dr Jacky W Y Lam Prof Lei Zheng Prof Ben Zhong Tang |
| Institution: | 1. Department of Chemistry, Hong Kong Branch of Chinese National Engineering, Research Center for Tissue Restoration and Reconstruction, Institute for Advanced Study, Department of Chemical and Biological Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
These authors contributed equally to this work.;2. Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515 China These authors contributed equally to this work.;3. School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006 China These authors contributed equally to this work.;4. Department of Chemistry, Hong Kong Branch of Chinese National Engineering, Research Center for Tissue Restoration and Reconstruction, Institute for Advanced Study, Department of Chemical and Biological Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China;5. Department of Chemistry, Hong Kong Branch of Chinese National Engineering, Research Center for Tissue Restoration and Reconstruction, Institute for Advanced Study, Department of Chemical and Biological Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China HKUST-Shenzhen Research Institute, No. 9 Yuexing 1st RD, South Area, Hi-tech Park, Nanshan, Shenzhen, 518057 China;6. Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515 China |
| Abstract: | Gold(I) N-heterocyclic carbene (AuI-NHC) complexes have emerged as potential anticancer agents owing to their high cytotoxicity and stability. Integration of their above unique functions with customized aggregation-induced emission (AIE) luminogens to achieve specific bioimaging and efficient theranostics to cancer is highly desirable but is rarely studied. Now, a series of novel AuI-NHC compounds were developed with AIE characteristics. A complex with a PPh3 ligand was selected out as it could achieve both prominent specific imaging of various cancer cells and efficient inhibition of their growth with negligible toxic effects on normal cells due to the targeting binding and strong inhibition towards thioredoxin reductase. This complex could also act as a powerful radiosensitizer to boost the anticancer efficacy with performance superior to that of popularly used auranofin. It holds great potential as a specific and effective theranostic drug in cancer diagnosis and precise therapy. |
| Keywords: | Aggregationsinduzierte Emission Gold(I)-Komplexe Radiosensibilisatoren Spezifische Biobildgebung Thioredoxin-Reduktase |