Enantioselective Dearomatization of Indoles by an Azoalkene-Enabled (3+2) Reaction: Access to Pyrroloindolines |
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| Authors: | Dr. Guang-Jian Mei Xiwen Tang Yildiz Tasdan Prof. Dr. Yixin Lu |
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| Affiliation: | Department of Chemistry, National University of Singapore, 3 Science Drive 3, 117543 Singapore, Singapore |
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| Abstract: | The enantioselective dearomatization of indoles by an organocatalytic (3+2) reaction has been established. The reaction makes use of simple indole derivatives as substrates, and employs azoalkenes reaction partners. A wide range of pyrroloindolines containing an all-carbon quaternary stereogenic center were readily prepared in high yields and with excellent enantioselectivities. |
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| Keywords: | Dearomatisierung Enantioselektivität Heterocyclen Organokatalyse Synthesemethoden |
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