Photosynthetic Tumor Oxygenation by Photosensitizer-Containing Cyanobacteria for Enhanced Photodynamic Therapy |
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| Authors: | Dr. Minfeng Huo Dr. Liying Wang Dr. Linlin Zhang Chenyang Wei Prof. Yu Chen Prof. Jianlin Shi |
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| Affiliation: | 1. State Key Laboratory of High Performance Ceramics, and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050 P. R. China;2. Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072 P. R. China These authors contributed equally to this work. |
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| Abstract: | Sustained tumor oxygenation is of critical importance during type-II photodynamic therapy (PDT), which depends on the intratumoral oxygen level for the generation of reactive oxygen species. Herein, the modification of photosynthetic cyanobacteria with the photosensitizer chlorin e6 (ce6) to form ce6-integrated photosensitive cells, termed ceCyan, is reported. Upon 660 nm laser irradiation, sustained photosynthetic O2 evolution by the cyanobacteria and the immediate generation of reactive singlet oxygen species (1O2) by the integrated photosensitizer could be almost simultaneously achieved for tumor therapy using type-II PDT both in vitro and in vivo. This work contributes a conceptual while practical paradigm for biocompatible and effective PDT using hybrid microorganisms, displaying a bright future in clinical PDT by microbiotic nanomedicine. |
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| Keywords: | Cyanobakterien Oxygenierung Photodynamische Therapie Photosensibilisator Photosynthese |
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