Choline chloride-urea deep eutectic solvent as an efficient media for the synthesis of propargylamines via organocuprate intermediate

A facile method for the synthesis of various propargylamines derivatives with different structural parts has been reported. The reaction has consisted of one-pot coupling between aldehydes, secondary amines and terminal alkynes using CuCl as a catalyst and choline chloride/urea DES as a cheap and biocompatible reaction media. The procedure is free of using toxic solvents and used CuCl as an available, inexpensive and non-toxic catalyst. Using this methodology, 15 different propargylamine derivatives were successfully synthesized at 60 °C in 15 hr, mostly in good yields.