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Fluorescence Self-Reporting Precipitation Polymerization Based on Aggregation-Induced Emission for Constructing Optical Nanoagents |
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| Authors: | Dr. Guan Wang Liangyu Zhou Prof. Pengfei Zhang Prof. Engui Zhao Lihua Zhou Dong Chen Prof. Jiangman Sun Prof. Xinggui Gu Prof. Wantai Yang Prof. Ben Zhong Tang |
| Affiliation: | 1. Beijing Advanced Innovation Center for Soft Matter Science and Engineering, College of Materials Science and Engineering, State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, North Third Ring Road 15, Chaoyang District, Beijing, 100029 China These authors contributed equally to this work.;2. Guangdong Key Laboratory of Nanomedicine, Shenzhen, Engineering Laboratory of Nanomedicine and Nanoformulations, CAS Key Lab for Health Informatics, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, 1068 Xueyuan Avenue, Shenzhen University Town, Shenzhen, 518055 P. R. China These authors contributed equally to this work.;3. School of Chemical Engineering and Energy Technology, Dongguan University of Technology, 1st University Road, Songshan Lake District, Dongguan, 523808 China;4. Guangdong Key Laboratory of Nanomedicine, Shenzhen, Engineering Laboratory of Nanomedicine and Nanoformulations, CAS Key Lab for Health Informatics, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, 1068 Xueyuan Avenue, Shenzhen University Town, Shenzhen, 518055 P. R. China;5. Beijing Advanced Innovation Center for Soft Matter Science and Engineering, College of Materials Science and Engineering, State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, North Third Ring Road 15, Chaoyang District, Beijing, 100029 China;6. Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, Institute for Advanced Study, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China |
| Abstract: | Precipitation polymerization is becoming increasingly popular in energy, environment and biomedicine. However, its proficient utilization highly relies on the mechanistic understanding of polymerization process. Now, a fluorescence self-reporting method based on aggregation-induced emission (AIE) is used to shed light on the mechanism of precipitation polymerization. The nucleation and growth processes during the copolymerization of a vinyl-modified AIEgen, styrene, and maleic anhydride can be sensitively monitored in real time. The phase-separation and dynamic hardening processes can be clearly discerned by tracking fluorescence changes. Moreover, polymeric fluorescent particles (PFPs) with uniform and tunable sizes can be obtained in a self-stabilized manner. These PFPs exhibit biolabeling and photosensitizing abilities and are used as superior optical nanoagents for photo-controllable immunotherapy, indicative of their great potential in biomedical applications. |
| Keywords: | Aggregationsinduzierte Emission Optische Nanoagenzien Photokontrollierbare Immuntherapie Fällungspolymerisation Fluoreszenz |