| A rapid synthesis of isoxazolo[5,4-d]pyrimidin-4（5H）-ones under microwave irradiation with solid acid catalysis in solvent-free conditions |
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| 引用本文： | A. Davoodnia,M. Roshani,S.H. Malaeke,M. Bakavoli.A rapid synthesis of isoxazolo[5,4-d]pyrimidin-4（5H）-ones under microwave irradiation with solid acid catalysis in solvent-free conditions[J].中国化学快报,2008,19(5):525-528. |
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| 作者姓名： | A. Davoodnia M. Roshani S.H. Malaeke M. Bakavoli |
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| 作者单位： | Department of Chemistry, School of Sciences, Islamic Azad University, Mashhad Branch, Mashhad 91735-413, Iran |
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| 摘 要： | A rapid and efficient method for the synthesis of isoxazolo5,4-d]pyrimidin-4（5H）-ones has been developed through cyclocondensation of 5-aminoisoxazole-4-carboxamides with orthoesters under conventional heating and solvent-free microwave irradiation with solid acid catalysis. In comparison, the reactions are faster and the yields are higher under microwave irradiation.
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| 关 键 词： | 合成方法 异氮杂化合物 嘧啶 微波照射 传统加热 |
| 收稿时间： | 3 December 2007 |
| 修稿时间： | 2007年12月3日 |
A rapid synthesis of isoxazolo[5,4-d]pyrimidin-4(5H)-ones under microwave irradiation with solid acid catalysis in solvent-free conditions |
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| A. Davoodnia, M. Roshani, S.H. Malaeke,M. Bakavoli.A rapid synthesis of isoxazolo[5,4-d]pyrimidin-4(5H)-ones under microwave irradiation with solid acid catalysis in solvent-free conditions[J].Chinese Chemical Letters,2008,19(5):525-528. |
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| Authors: | A Davoodnia M Roshani SH Malaeke M Bakavoli |
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| Institution: | Department of Chemistry, School of Sciences, Islamic Azad University, Mashhad Branch, Mashhad 91735-413, Iran |
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| Abstract: | A rapid and efficient method for the synthesis of isoxazolo5,4-d]pyrimidin-4(5H)-ones has been developed throughcyclocondensation of 5-aminoisoxazole-4-carboxamides with orthoesters under conventional heating and solvent-free microwaveirradiation with solid acid catalysis. In comparison, the reactions are faster and the yields are higher under microwave irradiation. |
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| Keywords: | Isoxaxolo[5 4-d]pyrimidin-4(5H)-ones Orthosesters Microwave irradiation Conventional heating |
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